Essay on effector functions of antibodies
Determination of individual subclasses is relevant in assessing primary immunodeficiencies or immune responses, especially if the total IgG or IgA concentration is not altered or elevated.
Humoral Immunity - an overview | ScienceDirect Topics
One of the primary functions of B cells in adaptive immunity is that of effecting a humoral response through the secretion of specific antibodies to address invading bodies and their toxic products. For example, the antibody isotype could switch from an IgM to an antibody of all possible classes e. IgG4, IgE. During this switch, the constant region of the heavy chain is changed, but not the variable region of the heavy chain.
- Antibody Function!
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The antibody class switch is critically dependent on the type of cytokine that is present. At a certain stage, the cell will lose its ability to undergo a switch to a class that has been generated before. Immune responses can vary with each antigen presented to the immune system, so quantifying specific antibody levels helps to interpret the immune response after immunization or vaccination.
Assessing human monoclonal antibody levels is also used widely as a diagnostic indicator to determine immunoglobulin-deficiency disorders, such as autoimmune diseases and gastrointestinal conditions that can be characterized by specific isotype deficiencies or varying concentrations of one or more isotypes. Disease states can range from the absence of one isotype class or subclass to a total deficiency of immunoglobulin classes.
The various isotypes also differ in their ability to bind to certain resins. Knowing the isotype is essential to assess the optimal purification techniques in order to gain maximum yield and purity of a desired antibody. Note: You clicked on an external link, which has been disabled in order to keep your shopping session open. Search Thermo Fisher Scientific. Search All.
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Soluble vs. membrane-bound immunoglobulins
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Structure of Antibody
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The Structure And Function Of Antibodies
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